Atrial natriuretic peptide (ANP) inhibits Na+ absorption Listen

Atrial natriuretic peptide (ANP) is released from the heart muscle during large strain as a result of high blood pressure or high fluid volume in the body. ANP inhibits sodium absorption in the renal collecting ducts, and inhibits the effect of angiotensin II and aldosterone. The consequence is reduced sodium and water reuptake, resulting in fluid loss and eventual normalization of fluid levels and blood pressure.